Usp1 Gene Summary [Rat]
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including monoubiquitinated protein deubiquitination; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of protein stability. Predicted to act upstream of or within skeletal system development. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human USP1 (ubiquitin specific peptidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp1 |
| Official Name | ubiquitin specific peptidase 1 [Source:RGD Symbol;Acc:1306461] |
| Ensembl ID | ENSRNOG00000007890 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 1 |
| Synonyms | ubiquitin specific peptidase 1, UBP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Usp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin thiolesterase
- cysteine endopeptidase
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
Pathways
Biological processes and signaling networks where the Usp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial cancer
- metabolic syndrome X
- osteosarcoma
- osteosarcomagenesis
- osteopenia
- non-insulin-dependent diabetes mellitus
- cyanosis
- MYC mutation positive B-cell lymphoma
role in cell
- number
- expression in
- proliferation
- migration
- invasion by
- growth
- phosphorylation in
- quantity
- cell cycle progression
- palbociclib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Usp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- DNA repair
- monoubiquitinated protein deubiquitination
- skeletal system development
- regulation of DNA repair
- proteolysis
- response to UV
- positive regulation of JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- cysteine-type endopeptidase activity
- peptidase activity