Timp4 Gene Summary [Rat]
Predicted to enable metalloendopeptidase inhibitor activity and zinc ion binding activity. Involved in several processes, including ovulation cycle; response to lipopolysaccharide; and response to peptide hormone. Located in extracellular space and sarcomere. Biomarker of abdominal aortic aneurysm; congestive heart failure; and renal hypertension. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Timp4 |
| Official Name | TIMP metallopeptidase inhibitor 4 [Source:RGD Symbol;Acc:69077] |
| Ensembl ID | ENSRNOG00000007955 |
| Bio databases IDs | |
| Aliases | TIMP metallopeptidase inhibitor 4 |
| Synonyms | LOC678834, TIMP metallopeptidase inhibitor 4, tissue inhibitor of metalloproteinase 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Timp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- zinc ion binding
- Tissue inhibitor of metalloproteinase
Pathways
Biological processes and signaling networks where the Timp4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- cancer
- abdominal cancer
- idiopathic pulmonary fibrosis
- osteoarthritis
- primary pulmonary hypertension
- squamous-cell carcinoma
- squamous cell cancer
- ulcerative colitis
- Dupuytren contracture
role in cell
- growth
- apoptosis
- cytostasis
- function
- migration
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- intracellular space
- perinuclear region
- sarcomere
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Timp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- Notch signaling pathway
- negative regulation of membrane protein ectodomain proteolysis
- negative regulation of endopeptidase activity
- response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- protease binding
- metalloendopeptidase inhibitor activity