Pcsk5 Gene Summary [Rat]
Predicted to enable peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of integrin-mediated signaling pathway; and positive regulation of smooth muscle cell-matrix adhesion. Located in Golgi apparatus subcompartment; perikaryon; and proximal dendrite. Biomarker of sciatic neuropathy. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcsk5 |
| Official Name | proprotein convertase subtilisin/kexin type 5 [Source:RGD Symbol;Acc:620326] |
| Ensembl ID | ENSRNOG00000012036 |
| Bio databases IDs | |
| Aliases | proprotein convertase subtilisin/kexin type 5 |
| Synonyms | b2b1549Clo, b2b585Clo, LOC100289618, LOC100290671, LOC100292811, PC5, PC5/6, PC5/6A, Pc5a, PC6, PC6A, PC6B, PCS 5/6, PROPROTEIN CONVERTASE 6, proprotein convertase subtilisin/kexin type 5, SPC6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcsk5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- Peptidase S8 pro-domain
- Giardia variant-specific surface protein
- Growth factor receptor domain IV
- Furin-like cysteine rich region
- Subtilase family
- peptidase
- PLAC (protease and lacunin) domain
- protein binding
- cleavage site
- Tumor necrosis factor receptor superfamily (TNFRSF)
- acidic domain
- Peptidase domain in the S8 and S53 families
- FU
- endopeptidase
- serine endopeptidase
- cytoplasmic domain
- Proprotein convertase P-domain
- Furin-like repeat, cysteine-rich
- Furin-like repeats
- pro domain
- cysteine rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- acute myeloid leukemia
- hypotension
- overall survival
- major depression
- lung cancer
- cognitive impairment
- carotid atherosclerosis
- bleeding
- multiple sclerosis
role in cell
- adhesion
- migration
- processing in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum lumen
- trans Golgi network
- dendrite initial segments
- Golgi cisternae
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcsk5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell signaling
- anterior/posterior pattern specification
- signal peptide processing
- embryonic skeletal system development
- renin secretion into blood stream
- embryo implantation
- heart development
- embryonic digestive tract development
- kidney development
- peptide biosynthetic process
- viral infectious cycle
- plasma lipoprotein particle remodeling
- limb morphogenesis
- protein processing
- peptide hormone processing
- respiratory tube development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- trans-Golgi network
- Golgi apparatus
- Golgi membrane
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- endopeptidase activity
- peptide binding
- peptidase activity