Ddx17 Gene Summary [Rat]
Predicted to enable several functions, including RNA binding activity; RNA helicase activity; and transcription coactivator activity. Predicted to be involved in several processes, including RNA metabolic process; nuclear receptor-mediated steroid hormone signaling pathway; and regulation of RNA metabolic process. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human DDX17 (DEAD-box helicase 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx17 |
| Official Name | DEAD-box helicase 17 [Source:RGD Symbol;Acc:1304945] |
| Ensembl ID | ENSRNOG00000051170 |
| Bio databases IDs | |
| Aliases | DEAD-box helicase 17 |
| Synonyms | 2610007K22RIK, A430025E01Rik, AA521056, DEAD-box helicase 17, DEAD-box protein p72, DEAD/H box RNA helicase p72, Gm926, P72, RH70 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ddx17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylation site
- transcription co-activator
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- chromatin binding
- enzyme
- protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- RNA dependent ATPase
- DNA binding
- RNA binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- organismal death
- metastasis
- neoplasia
- cholecystitis
- tubulovillous adenoma
- mixed neoplasia
- adenoma formation
- gastrointestinal neoplasia
- breast cancer
role in cell
- expression in
- activation in
- apoptosis
- cell cycle progression
- phosphorylation in
- invasion by
- migration
- replication in
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- spliceosomes
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ddx17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myoblast differentiation
- RNA processing
- rRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- immune system process
- regulation of transcription from RNA polymerase II promoter
- regulation of alternative nuclear mRNA splicing, via spliceosome
- alternative nuclear mRNA splicing, via spliceosome
- defense response to virus
- epithelial to mesenchymal transition
- gene silencing by RNA
- androgen receptor signaling pathway
- intracellular estrogen receptor signaling pathway
- regulation of skeletal muscle cell differentiation
- miRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- membrane
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- transcription coactivator activity
- RNA helicase activity
- RNA-dependent ATPase activity
- ribonucleoprotein complex binding
- mRNA 3'-UTR binding