Krt7 Gene Summary [Rat]
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be active in keratin filament. Orthologous to human KRT7 (keratin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt7 |
| Official Name | keratin 7 [Source:RGD Symbol;Acc:1310865] |
| Ensembl ID | ENSRNOG00000008057 |
| Bio databases IDs | |
| Aliases | keratin 7 |
| Synonyms | CK7, Cytokeratin 7, D15Wsu77e, K2C7, K7, keratin 7, Keratin complex 2, basic, gene 7, KRT2-7, SARCOLECTIN, SCL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR/MLP1/MLP2-like protein
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- protein binding
- Intermediate filament protein
- Domain of unknown function (DUF5082)
- Keratin type II head
Pathways
Biological processes and signaling networks where the Krt7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- squamous cell cancer
- adenoma formation
- esophageal carcinoma formation
- breast cancer
- organismal death
- neuroendocrine carcinoma
- neuroendocrine cancer
- serous ovarian cancer
regulates
- KRT7
- DNA promoter
- DNA endogenous promoter
- histone H3
- histone H4
role in cell
- expression in
- proliferation
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intermediate filament cytoskeleton
- apical compartment
- cytosol
- nucleoli
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinization
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- keratin filament
- intermediate filament cytoskeleton
- cytoplasm
- cytosol
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding