Gins1 Gene Summary [Rat]
Predicted to act upstream of or within DNA replication and inner cell mass cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CMG complex and GINS complex. Human ortholog(s) of this gene implicated in immunodeficiency 55. Orthologous to human GINS1 (GINS complex subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gins1 |
| Official Name | GINS complex subunit 1 [Source:RGD Symbol;Acc:1562246] |
| Ensembl ID | ENSRNOG00000008091 |
| Bio databases IDs | |
| Aliases | GINS complex subunit 1 |
| Synonyms | 2810418N01Rik, Gins4, GINS complex subunit 1, IMD55, KIAA0186, mKIAA0186, PSF1, RGD1562246 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gins1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-helical domain of GINS complex proteins (Sld5, Psf1, Psf2 and Psf3)
- GINS_B
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- immunodeficiency 55
- hepatitis B virus-related hepatocellular carcinoma
- HER2 negative hormone receptor negative breast cancer
- organismal death
- combined immunodeficiency
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- proliferation
- doxorubicin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gins1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner cell mass cell proliferation
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- CMG complex
- cytoplasm
- GINS complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding