Mfng Gene Summary [Rat]
Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in marginal zone B cell differentiation and regulation of Notch signaling pathway. Predicted to act upstream of or within blastocyst formation and positive regulation of Notch signaling pathway. Predicted to be located in endomembrane system and membrane. Orthologous to human MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mfng |
| Official Name | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Source:RGD Symbol;Acc:735126] |
| Ensembl ID | ENSRNOG00000008133 |
| Bio databases IDs | |
| Aliases | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| Synonyms | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, MFNG O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mfng often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylglucosaminyltransferase
- galactosyltransferase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Mfng gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic autoimmune syndrome
- non-small cell lung cancer
- androgenic alopecia
role in cell
- proliferation
- expression in
- migration
- differentiation
- activation in
- frequency
- number
- binding
- generation
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mfng gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- marginal zone B cell differentiation
- regulation of Notch signaling pathway
- blastocyst formation
- pattern specification process
- positive regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity