Notch4 Gene Summary [Rat]
Predicted to enable GTPase regulator activity. Predicted to be involved in positive regulation of inflammatory response. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of leukocyte chemotaxis. Predicted to be located in plasma membrane. Orthologous to human GPSM3 (G protein signaling modulator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Notch4 |
| Official Name | notch receptor 4 [Source:RGD Symbol;Acc:1303282] |
| Ensembl ID | ENSRNOG00000000442 |
| Bio databases IDs | |
| Aliases | notch receptor 4 |
| Synonyms | INT3, LOC224712, N4, notch receptor 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Notch4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- Ankyrin repeats (many copies)
- JMTM_Notch_APP
- RAM domain
- signaling receptor activity
- nucleic acid binding
- ectodomain
- Human growth factor-like EGF
- LNR domain
- calcium ion binding
- Ankyrin repeats (3 copies)
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
- EGF_CA
- NOTCH protein
- cytoplasmic domain
- double-stranded DNA binding
- intracellular domain
- EGF domain
- ankyrin repeats
- notch binding
Pathways
Biological processes and signaling networks where the Notch4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic interstitial cystitis
- multiple sclerosis
- epithelial cancer
- liver cancer
- neoplasia
- hepatocellular carcinoma
- Takayasu arteritis
- Alzheimer disease
- asthma
- COVID-19
role in cell
- expression in
- apoptosis
- growth
- phosphorylation in
- proliferation
- morphogenesis
- production in
- differentiation
- activation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Notch4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell adhesion molecule production
- hemopoiesis
- positive regulation of transcription of Notch receptor target
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of endothelial cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- morphogenesis of a branching structure
- mammary gland development
- wound healing
- patterning of blood vessels
- positive regulation of transcription, DNA-dependent
- negative regulation of cell differentiation
- vasculature development
- positive regulation of smooth muscle cell differentiation
- cell differentiation
- epithelial to mesenchymal transition
- cell fate determination
- negative regulation of cell-cell adhesion mediated by cadherin
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytosol
- Golgi membrane
- extracellular region
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- signaling receptor activity
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- Notch binding