Hs6st1 Gene Summary [Rat]
Predicted to enable heparan sulfate 6-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process and neuron development. Predicted to act upstream of or within angiogenesis; labyrinthine layer blood vessel development; and lung alveolus development. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hs6st1 |
| Official Name | heparan sulfate 6-O-sulfotransferase 1 [Source:RGD Symbol;Acc:1309218] |
| Ensembl ID | ENSRNOG00000014516 |
| Bio databases IDs | |
| Aliases | heparan sulfate 6-O-sulfotransferase 1 |
| Synonyms | 6Ost1, heparan sulfate 6-O-sulfotransferase 1, heparan sulphate 6 o sulphotransferase, heparan sulphate 6-O-sulphotransferase 1, heparan sulphate 6 sulphotransferase, HH15, HS6ST |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hs6st1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- heparan sulfate 6-O-sulfotransferase
- enzyme
- protein binding
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the Hs6st1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypogonadotropic hypogonadism type 15 with anosmia
- growth failure
- susceptibility to hypogonadotropic hypogonadism 15 with anosmia
- hypoplasia
- susceptibility to hypogonadotropic hypogonadism type 15
- idiopathic pulmonary fibrosis
role in cell
- proliferation
- expression in
- activation in
- binding in
- accumulation
- formation in
- binding
- tubulation
- depletion
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hs6st1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, enzymatic modification
- lung alveolus development
- labyrinthine layer blood vessel development
- angiogenesis
- neuron development
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- heparan sulfate 6-O-sulfotransferase activity
- sulfotransferase activity