Nxn Gene Summary [Rat]
Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in several processes, including Wnt signaling pathway; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Predicted to act upstream of or within in utero embryonic development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome 2. Orthologous to human NXN (nucleoredoxin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nxn |
| Official Name | nucleoredoxin [Source:RGD Symbol;Acc:1310489] |
| Ensembl ID | ENSRNOG00000008178 |
| Bio databases IDs | |
| Aliases | nucleoredoxin |
| Synonyms | l11Jus13, NRX, Nucleoredoxin, RRS2, TRG-4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nxn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thioredoxin-like domain
- Thioredoxin-like
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- thioredoxin
- thioredoxin-disulfide reductase
Pathways
Biological processes and signaling networks where the Nxn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- metastasis
- neoplasia
- autosomal recessive Robinow syndrome type 2
- colorectal cancer
- Alzheimer disease
- liver cancer
- epithelial cancer
- organismal death
- hepatocellular carcinoma
role in cell
- proliferation
- activation in
- invasion by
- binding in
- migration
- deubiquitination in
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nxn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- cell differentiation
- circulatory system development
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- negative regulation of protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- thioredoxin-disulfide reductase activity