Flii Gene Summary [Rat]
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin cytoskeleton organization; actin filament severing; and barbed-end actin filament capping. Predicted to be located in several cellular components, including brush border; cytoskeleton; and nucleoplasm. Predicted to be active in actin cytoskeleton; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flii |
| Official Name | FLII, actin remodeling protein [Source:RGD Symbol;Acc:1307590] |
| Ensembl ID | ENSRNOG00000004159 |
| Bio databases IDs | |
| Aliases | FLII, actin remodeling protein |
| Synonyms | 3632430F08Rik, CMD2J, FLI, Fli1, flightless I actin binding protein, FLII actin remodeling protein, FLII, actin remodeling protein, FLIIH, FLIL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Flii often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- leucine rich domain
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- Gelsolin repeat
- DNA binding domain
- actin binding
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary dilated cardiomyopathy
- dilated cardiomyopathy type 2J
- cardiomyopathy
- serous ovarian adenocarcinoma
- serous ovarian cancer
- infection by HIV-1
role in cell
- expression in
- proliferation
- survival
- activation in
- organization
- shortening
- severing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane/cytoplasmic fraction
- Cytoplasm
- perinuclear region
- podosomes
- actin cytoskeleton
- centrosome
- cytosol
- nucleoplasm
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Flii gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myofibril assembly
- barbed-end actin filament capping
- actin filament severing
- actin polymerization or depolymerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- brush border
- focal adhesion
- cytoplasm
- centriolar satellite
- actin cytoskeleton
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- actin binding