Nxn Gene Summary [Mouse]
Enables thioredoxin-disulfide reductase (NADPH) activity. Involved in circulatory system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Acts upstream of or within in utero embryonic development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome 2. Orthologous to human NXN (nucleoredoxin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nxn |
| Official Name | nucleoredoxin [Source:MGI Symbol;Acc:MGI:109331] |
| Ensembl ID | ENSMUSG00000020844 |
| Bio databases IDs | |
| Aliases | nucleoredoxin |
| Synonyms | l11Jus13, NRX, Nucleoredoxin, RRS2, TRG-4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nxn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thioredoxin-like domain
- Thioredoxin-like
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- thioredoxin
- thioredoxin-disulfide reductase
Pathways
Biological processes and signaling networks where the Nxn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- metastasis
- neoplasia
- autosomal recessive Robinow syndrome type 2
- colorectal cancer
- Alzheimer disease
- liver cancer
- epithelial cancer
- organismal death
- hepatocellular carcinoma
phenotypes
- abnormal auditory brainstem response
- abnormal craniofacial morphology
- abnormal cranium morphology
- abnormal digit morphology
- abnormal embryo size
- abnormal eye morphology
- abnormal eyelid morphology
- abnormal facial morphology
- abnormal head shape
- abnormal head size
- abnormal mammary gland morphology
- abnormal optic disk morphology
- abnormal retinal blood vessel morphology
- abnormal skin coloration
- abnormal snout morphology
- anophthalmia
- decreased cardiac muscle contractility
- decreased circulating bilirubin level
- decreased circulating triglyceride level
- decreased lean body mass
- decreased mean corpuscular hemoglobin
- decreased mean corpuscular hemoglobin concentration
- decreased mean corpuscular volume
- decreased mean platelet volume
- decreased red blood cell distribution width
- decreased spleen weight
- decreased total body fat amount
- hypoactivity
- increased circulating HDL cholesterol level
- increased circulating triglyceride level
- increased grip strength
- irregularly shaped pupil
- pallor
- preweaning lethality complete penetrance
- preweaning lethality incomplete penetrance
- respiratory system phenotype
- short tibia
- small adrenal glands
- abnormal Mullerian duct morphology
- abnormal airway resistance
- abnormal cardiac muscle contractility
- abnormal cell physiology
- abnormal circulating alkaline phosphatase level
- abnormal lean body mass
- abnormal locomotor activation
- abnormal mean corpuscular hemoglobin
- abnormal mean corpuscular volume
- abnormal monocyte cell number
- abnormal sternum morphology
- abnormal tibia morphology
- abnormal vitelline vein topology
- absent stapedial artery
- atrioventricular septal defect
- cleft palate
- decreased fetal size
- decreased intestine length
- double outlet right ventricle
- enlarged liver sinusoidal spaces
- herniated liver
- increased osteoblast cell number
- perimembraneous ventricular septal defect
- perinatal lethality complete penetrance
- persistent truncus arteriosis
- small frontal bone
- split xiphoid process
- ventricular septal defect
role in cell
- proliferation
- activation in
- invasion by
- binding in
- migration
- deubiquitination in
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nxn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- cell differentiation
- circulatory system development
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- negative regulation of protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- thioredoxin-disulfide reductase activity