Cr1l Gene Summary [Mouse]
Predicted to enable complement receptor activity and opsonin binding activity. Acts upstream of or within several processes, including cellular response to hypoxia; complement activation; and negative regulation of complement activation. Located in basolateral plasma membrane and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in malaria. Orthologous to several human genes including CR1L (complement C3b/C4b receptor 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cr1l |
| Official Name | complement component (3b/4b) receptor 1-like [Source:MGI Symbol;Acc:MGI:88513] |
| Ensembl ID | ENSMUSG00000016481 |
| Bio databases IDs | |
| Aliases | complement component (3b/4b) receptor 1-like |
| Synonyms | complement C3b/C4b receptor 1 like, Cr1, CRRY, LOC100911729, Mcp, mCRY |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cr1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- extracellular domain
- complement receptor
- cytoplasmic domain
- protein binding
- Sushi repeat (SCR repeat)
- complement component C3b receptor
- transmembrane receptor
- SUSHI repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- T-cell lymphopenia
- Alzheimer disease
- dextran sodium sulfate-induced colitis
- cleft lip
- gastroesophageal reflux
- shock response
- reperfusion injury
- glomerulosclerosis
- renal failure
role in cell
- phosphorylation in
- proliferation
- production in
- activation in
- apoptosis
- activation
- differentiation
- survival
- function
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- cell surface
- basolateral cell surfaces
- plasma membrane extracellular face
- basolateral membrane
- basal membrane
- membrane rafts
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cr1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of complement activation, classical pathway
- T cell mediated immunity
- regulation of complement activation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding