Sec23b Gene Summary [Rat]
Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be located in cytosol; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in Cowden syndrome 7 and congenital dyserythropoietic anemia type II. Orthologous to human SEC23B (SEC23 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec23b |
| Official Name | Sec23 homolog B, coat complex II component [Source:RGD Symbol;Acc:1310699] |
| Ensembl ID | ENSRNOG00000008411 |
| Bio databases IDs | |
| Aliases | Sec23 homolog B, coat complex II component |
| Synonyms | CDA-II, CDAN2, CWS7, HEMPAS, hSec23B, SEC23 homolog B, COPII coat complex component |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sec23b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec23/Sec24 helical domain
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- Sec23/Sec24 trunk domain
- Gelsolin repeat
- vWFA
- Sec23/Sec24 beta-sandwich domain
- protein binding
- Sec23/Sec24 zinc finger
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- dyserythropoietic congenital anemia type II
- severe COVID-19
- neonatal late-onset sepsis
- Cowden disease type 7
- preeclampsia
- congenital dyserythropoietic anemia
- neuroticism
- refractive error
role in cell
- apoptosis
- growth
- number
- morphology
- cell death
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum mitochondria contact site
- endomembrane system
- perinuclear region
- Endoplasmic Reticulum
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sec23b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cargo loading into COPII-coated vesicle
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- endomembrane system
- cytosol
- endoplasmic reticulum exit site
- endoplasmic reticulum
- COPII vesicle coat
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- GTPase activator activity