Epha5 Gene Summary [Rat]
Enables ephrin receptor activity and growth factor binding activity. Involved in dendritic spine morphogenesis; ephrin receptor signaling pathway; and positive regulation of CREB transcription factor activity. Acts upstream of or within negative regulation of cell adhesion. Located in axon and plasma membrane. Orthologous to human EPHA5 (EPH receptor A5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epha5 |
| Official Name | EPH receptor A5 [Source:RGD Symbol;Acc:620831] |
| Ensembl ID | ENSRNOG00000002024 |
| Bio databases IDs | |
| Aliases | EPH receptor A5 |
| Synonyms | AW125296, bsk, CEK7, EHK-1, EK7, ELS1, Els1., EPH receptor A5, HEK7, Rek7, TYRO4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epha5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ligand Binding Domain of Ephrin Receptors
- Protein kinase (unclassified specificity)
- Tyrosine-protein kinase ephrin type A/B receptor-like
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- ephrin receptor
- protein binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Sterile alpha motif
- GPI-linked ephrin receptor
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- FN3
- SAM domain (Sterile alpha motif)
- PDZ binding motif
- Tyrosine kinase, catalytic domain
- Ephrin receptor ligand binding domain
- growth factor binding
Pathways
Biological processes and signaling networks where the Epha5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- clear cell ovarian cancer
- Alzheimer disease
- schizophrenia
- natural killer/T-cell lymphoma
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
- dermatological disorder
- chemotherapy-induced peripheral neuropathy
- clear-cell ovarian carcinoma
regulates
- EFNA5
- proinsulin
- GTPase
role in cell
- growth
- adhesion
- organization
- response by
- morphogenesis
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- perinuclear region
- cellular membrane
- plasma membrane extracellular face
- dendrite initial segments
- rough endoplasmatic reticulum
- perikaryon
- axons
- dendrites
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epha5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- regulation of actin cytoskeleton organization
- regulation of GTPase activity
- ephrin receptor signaling pathway
- axon guidance
- positive regulation of CREB transcription factor activity
- hippocampus development
- neuron development
- protein phosphorylation
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- dendrite
- perinuclear region of cytoplasm
- external side of plasma membrane
- rough endoplasmic reticulum
- neuronal cell body
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- GPI-linked ephrin receptor activity
- ephrin receptor activity
- transmembrane-ephrin receptor activity