Acox3 Gene Summary [Rat]
Enables fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Involved in fatty acid beta-oxidation using acyl-CoA oxidase. Located in peroxisome. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acox3 |
| Official Name | acyl-CoA oxidase 3, pristanoyl [Source:RGD Symbol;Acc:69245] |
| Ensembl ID | ENSRNOG00000008474 |
| Bio databases IDs | |
| Aliases | acyl-CoA oxidase 3, pristanoyl |
| Synonyms | acyl-CoA oxidase 3, pristanoyl, acyl-Coenzyme A oxidase 3, pristanoyl, EST-s59, PCOX, Pristanoyl-CoA Oxidase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acox3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acyl-CoA oxidase
- flavin adenine dinucleotide binding
- Acyl-CoA dehydrogenase, C-terminal domain
- acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, middle domain
- fatty acid binding
- Acyl-coenzyme A oxidase N-terminal
- pristanoyl-CoA oxidase
- enzyme
Pathways
Biological processes and signaling networks where the Acox3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- schizophrenia
- diabetic peripheral neuropathy
- hemorrhoid
- Sengers syndrome
regulates
- palmitoyl-coenzyme A
- 2-methylhexanoyl-coenzyme A
- pristanoyl-coenzyme A
- fatty acid
- lignoceroyl-coenzyme A
- hexadecanedioyl-coenzyme A
- 2-methylpalmitoyl-coenzyme A
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acox3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation using acyl-CoA oxidase
- lipid homeostasis
Cellular Component
Where in the cell the gene product is active
- peroxisome
- membrane
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- FAD binding
- fatty acid binding
- flavin adenine dinucleotide binding
- pristanoyl-CoA oxidase activity