Ddr2 Gene Summary [Rat]
Enables collagen binding activity. Involved in several processes, including negative regulation of programmed cell death; positive regulation of ERK1 and ERK2 cascade; and positive regulation of cell population proliferation. Located in apical plasma membrane. Used to study alcoholic liver cirrhosis. Biomarker of alcoholic liver cirrhosis. Human ortholog(s) of this gene implicated in bone disease (multiple) and gastrointestinal system cancer (multiple). Orthologous to human DDR2 (discoidin domain receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddr2 |
| Official Name | discoidin domain receptor tyrosine kinase 2 [Source:RGD Symbol;Acc:619855] |
| Ensembl ID | ENSRNOG00000002881 |
| Bio databases IDs | |
| Aliases | discoidin domain receptor tyrosine kinase 2 |
| Synonyms | AI838577, discoidin domain receptor family, member 2, discoidin domain receptor tyrosine kinase 2, LOC686988, LOC98434, MIG20a, NTRKR3, TKT, TYRO10, WRCN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ddr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Protein kinase (unclassified specificity)
- Coagulation factor 5/8 C-terminal domain, discoidin domain
- Protein tyrosine and serine/threonine kinase
- ectodomain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- collagen receptor
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- cytoplasmic domain
- transmembrane receptor protein tyrosine kinase
- F5/8 type C domain
- intracellular domain
- collagen binding
- Tyrosine kinase, catalytic domain
- FA58C
Pathways
Biological processes and signaling networks where the Ddr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-squamous lung carcinoma
- hepatocellular carcinoma
- epithelial cancer
- breast cancer
- precursor B-cell acute lymphoblastic leukemia
- neoplasia
- metastatic progressive colorectal cancer
- metastatic gastrointestinal stromal tumor
- NRAS codon 12 mutation positive colorectal cancer
- acute lymphoblastic lymphoma
role in cell
- migration
- expression in
- phosphorylation in
- proliferation
- activation in
- apoptosis
- formation
- differentiation
- crizotinib sensitivity
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- actin cytoskeleton
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ddr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- multicellular organismal development
- protein autophosphorylation
- cell adhesion
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of osteoblast differentiation
- positive regulation of collagen biosynthetic process
- ossification
- positive regulation of fibroblast proliferation
- regulation of extracellular matrix disassembly
- positive regulation of kinase activity
- positive regulation of neuron projection development
- regulation of tissue remodeling
- cellular response to hypoxia
- response to muscle stretch
- biomineral tissue development
- regulation of bone mineralization
- positive regulation of hepatic stellate cell activation
- positive regulation of wound healing
- positive regulation of G1/S transition of mitotic cell cycle
- signal transduction
- transmembrane receptor protein tyrosine kinase signaling pathway
- collagen-activated tyrosine kinase receptor signaling pathway
- cellular response to transforming growth factor beta stimulus
- positive regulation of extracellular matrix disassembly
- endochondral bone growth
- positive regulation of protein kinase activity
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- chondrocyte proliferation
- collagen fibril organization
- positive regulation of fibroblast migration
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- actin cytoskeleton
- receptor complex
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- collagen binding
- transmembrane receptor protein tyrosine kinase activity
- protein tyrosine kinase collagen receptor activity