Cep55 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Predicted to be located in Flemming body; centrosome; and intercellular bridge. Predicted to be active in midbody. Human ortholog(s) of this gene implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Orthologous to human CEP55 (centrosomal protein 55). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cep55 |
| Official Name | centrosomal protein 55 [Source:RGD Symbol;Acc:1305340] |
| Ensembl ID | ENSRNOG00000016377 |
| Bio databases IDs | |
| Aliases | centrosomal protein 55 |
| Synonyms | 1200008O12Rik, 2700032M20Rik, C10orf3, centrosomal protein 55, CT111, FLJ10540, MARCH, RGD1305340, URCC6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cep55 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hinge domain
- coiled-coil domain
- TSG101 and ALIX binding domain of CEP55
- protein binding
- identical protein binding
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- lung squamous cell carcinoma
- invasive breast cancer
- colon adenocarcinoma
- colorectal cancer
- osteosarcoma
- hepatocellular carcinoma
- colon cancer
- rectum cancer
- oral cancer
role in cell
- expression in
- apoptosis
- proliferation
- phosphorylation in
- morphology
- cytokinesis
- migration
- G2/M phase
- damage in
- abscission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centriolar satellite
- centrosome
- midbody
- Flemming body
- cytoplasmic bridges
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cep55 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization
- regulation of protein kinase B signaling cascade
- cytokinesis after mitosis
- nucleus organization
- mitotic metaphase plate congression
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- centrosome
- cytoplasm
- centriole
- cleavage furrow
- membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding