Antxr1 Gene Summary [Rat]
Predicted to enable actin filament binding activity; collagen binding activity; and transmembrane signaling receptor activity. Predicted to be involved in actin cytoskeleton organization and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within blood vessel development; negative regulation of extracellular matrix assembly; and positive regulation of metallopeptidase activity. Predicted to be located in external side of plasma membrane; filopodium membrane; and lamellipodium membrane. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in GAPO syndrome and colorectal carcinoma. Orthologous to human ANTXR1 (ANTXR cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Antxr1 |
| Official Name | ANTXR cell adhesion molecule 1 [Source:RGD Symbol;Acc:1307144] |
| Ensembl ID | ENSRNOG00000008678 |
| Bio databases IDs | |
| Aliases | ANTXR cell adhesion molecule 1 |
| Synonyms | 2310008J16Rik, 2810405N18Rik, anthrax toxin receptor 1, Antrx1, ANTXR cell adhesion molecule 1, ATR, ATR1, GAPO, TEM8, TEM8 splice variant 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Antxr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIDAS motif
- extracellular domain
- von Willebrand factor (vWF) type A domain
- von Willebrand factor type A domain
- inserted domain
- protein binding
- Anthrax receptor C-terminus region
- actin filament binding
- cytoplasmic domain
- vWFA
- transmembrane domain
- intracellular domain
- collagen binding
- domain I
- Anthrax receptor extracellular domain
- cytosolic tail domain
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- neoplasia
- infantile hemangioma formation
- breast carcinoma
- colorectal cancer
- murine Lewis lung carcinoma
- lung carcinoma process
- open-angle glaucoma
- susceptibility to capillary infantile hemangioma
- growth retardation, alopecia, pseudoanodontia, and progressive visual impairment syndrome
role in cell
- cell viability
- expression in
- growth
- activation in
- quantity
- cell spreading
- killing
- cell death
- survival
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- Cytoplasm
- cell surface
- cellular membrane
- basolateral cell surfaces
- plasma membrane extracellular face
- endosomal membrane
- membrane rafts
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Antxr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blood vessel development
- substrate adhesion-dependent cell spreading
- reproductive process
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- filopodium membrane
- external side of plasma membrane
- endosome membrane
- plasma membrane
- lamellipodium membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- transmembrane signaling receptor activity
- protein binding
- collagen binding
- metal ion binding