Pklr Gene Summary [Rat]
Enables monosaccharide binding activity and pyruvate kinase activity. Involved in several processes, including cellular response to epinephrine stimulus; cellular response to insulin stimulus; and monocarboxylic acid metabolic process. Predicted to be located in plasma membrane. Predicted to be part of pyruvate kinase complex. Predicted to be active in cytosol. Biomarker of hyperglycemia and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; congenital nonspherocytic hemolytic anemia 2; malaria; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pklr |
| Official Name | pyruvate kinase L/R [Source:RGD Symbol;Acc:3336] |
| Ensembl ID | ENSRNOG00000020420 |
| Bio databases IDs | |
| Aliases | pyruvate kinase L/R |
| Synonyms | CNSHA2, L-PK, PK1, PKL, Pklg, PKRL, Pyruvate kinase, liver and rbc, pyruvate kinase liver and red blood cell, pyruvate kinase L/R, R-PK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pklr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- monosaccharide binding
- Pyruvate_Kinase
- pyruvate kinase
- protein binding
- Pyruvate kinase, alpha/beta domain
Pathways
Biological processes and signaling networks where the Pklr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- pyruvate kinase protein deficiency anemia
- non-transfusion dependent beta-thalassemia
- hemolytic anemia
- alpha thalassemia
- elevated adenosine triphosphate of erythrocytes
- major depression
- androgenic alopecia
- anemia
- transfusion dependent beta thalassemia
role in cell
- survival
- quantity
- glycolysis in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pklr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- pyruvate biosynthetic process
- response to glucose stimulus
- response to hypoxia
- cellular response to epinephrine stimulus
- response to ATP
- glycolysis
- response to metal ion
- response to cAMP
- response to nutrient
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- pyruvate kinase activity
- protein binding
- potassium ion binding
- monosaccharide binding
- kinase activity