Ccar2 Gene Summary [Rat]
Predicted to enable RNA polymerase II complex binding activity and enzyme inhibitor activity. Predicted to be involved in several processes, including mitochondrial fragmentation involved in apoptotic process; regulation of primary metabolic process; and regulation of signal transduction. Predicted to be located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Predicted to be part of DBIRD complex. Predicted to be active in nucleus. Orthologous to human CCAR2 (cell cycle and apoptosis regulator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccar2 |
| Official Name | cell cycle and apoptosis regulator 2 [Source:RGD Symbol;Acc:1309922] |
| Ensembl ID | ENSRNOG00000018295 |
| Bio databases IDs | |
| Aliases | cell cycle and apoptosis regulator 2 |
| Synonyms | 2610301G19Rik, cell cycle activator and apoptosis regulator 2, cell cycle and apoptosis regulator 2, DBC-1, KIAA1967, mKIAA1967, NET35, p30 DBC, RGD1309922 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccar2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BURAN domain
- DBC1
- peptidase
- enzyme inhibitor activity
- enzyme binding
- leucine zipper domain
- protein binding
- S1-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- tinnitus
- hemorrhoid
- refractive error
- experimental autoimmune myasthenia gravis
- insomnia
role in cell
- expression in
- apoptosis
- growth
- migration
- binding in
- clustering
- acetylation in
- ubiquitination in
- elongation in
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle apparatus
- Nucleus
- mitochondrial matrix
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccar2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of protein deacetylation
- positive regulation of canonical Wnt receptor signaling pathway
- response to UV
- mitochondrial fragmentation involved in apoptotic process
- mRNA processing
- regulation of circadian rhythm
- response to DNA damage stimulus
- regulation of protein stability
- negative regulation of catalytic activity
- negative regulation of transcription, DNA-dependent
- rhythmic process
- negative regulation of cell growth
- positive regulation of apoptotic process
- regulation of transcription elongation, DNA-dependent
- positive regulation of DNA damage checkpoint
- Wnt receptor signaling pathway
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- DBIRD complex
- cytoplasm
- mitochondrial matrix
- spindle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- enzyme inhibitor activity
- unfolded protein binding
- adenyl-nucleotide exchange factor activity
- RNA polymerase II core binding
- enzyme binding