Mpp5 Gene Summary [Rat]
Predicted to enable identical protein binding activity and protein domain specific binding activity. Involved in myelin assembly and protein localization to plasma membrane. Part of protein-containing complex. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mpp5 |
| Official Name | membrane palmitoylated protein 5 [Source:RGD Symbol;Acc:1308071] |
| Ensembl ID | ENSRNOG00000008788 |
| Bio databases IDs | |
| Aliases | membrane palmitoylated protein 5 |
| Synonyms | 3830420B02Rik, MPP5, protein associated with LIN7 1, MAGUK family member, protein associated with LIN7 1, MAGUK p55 family member |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mpp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanylate kinase
- Domain present in PSD-95, Dlg, and ZO-1/2
- NK
- canonical PDZ domain
- U1 domain
- protein domain specific binding
- protein binding
- PDZ domain
- identical protein binding
- L27_N
- Src Homology 3 domain superfamily
- L27 domain
Pathways
Biological processes and signaling networks where the Mpp5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- apical compartment
- cellular membrane
- lateral plasma membrane
- paranodal loops
- paranodes
- myelin sheath inner loop
- myelin sheath
- Schmidt-Lanterman incisures
- tight junctions
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mpp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to myelin sheath abaxonal region
- cerebral cortex development
- generation of neurons
- central nervous system neuron development
- morphogenesis of an epithelial sheet
- establishment or maintenance of epithelial cell apical/basal polarity
- gene expression
- peripheral nervous system myelin maintenance
- establishment or maintenance of polarity of embryonic epithelium
- myelin assembly
- regulation of transforming growth factor beta receptor signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- lateral loop
- Golgi apparatus
- perikaryon
- plasma membrane
- tight junction
- adherens junction
- extracellular vesicular exosome
- myelin sheath adaxonal region
- cytoplasm
- Schmidt-Lanterman incisure
- apical junction complex
- macromolecular complex
- apical plasma membrane
- axon
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein domain specific binding
- protein binding