Mag Gene Summary [Rat]
Enables carboxylic acid binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of neuron differentiation; and regulation of neurogenesis. Located in several cellular components, including Schmidt-Lanterman incisure; mesaxon; and myelin sheath adaxonal region. Used to study middle cerebral artery infarction and sciatic neuropathy. Biomarker of nerve compression syndrome. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 75. Orthologous to human MAG (myelin associated glycoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mag |
| Official Name | myelin-associated glycoprotein [Source:RGD Symbol;Acc:3035] |
| Ensembl ID | ENSRNOG00000021023 |
| Bio databases IDs | |
| Aliases | myelin-associated glycoprotein |
| Synonyms | 1B236, GMA, myelin-associated glycoprotein, SIGLEC4, SIGLEC-4A, SPG75 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mag often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- sphingolipid binding
- lipid binding
- protein kinase binding
- immunoglobulin domain
- ectodomain
- RGD motif
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- binding protein
- Immunoglobulin like
- protein homodimerization
Pathways
Biological processes and signaling networks where the Mag gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- complicated hereditary spastic paraplegia
- autosomal recessive spastic paraplegia type 75
- glioblastoma
- glioblastoma cancer
- Alzheimer disease
- tremor
- conduction block
- Huntington disease
- hypomyelination
role in cell
- binding in
- proliferation
- growth
- apoptosis
- adhesion
- outgrowth
- morphology
- priming
- length
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- myelin-derived rafts
- axon component
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- inner membrane
- periaxonal membranes
- paranodal loops
- paranodes
- myelin sheath inner loop
- nodal axolemma
- myelin sheath
- mesaxons
- Schmidt-Lanterman incisures
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mag gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to mechanical stimulus
- negative regulation of axon extension
- negative regulation of neuron projection development
- central nervous system myelin formation
- negative regulation of neuron differentiation
- cell adhesion
- positive regulation of astrocyte differentiation
- transmission of nerve impulse
- axon regeneration
- negative regulation of neuron apoptotic process
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- compact myelin
- paranode region of axon
- myelin sheath
- myelin sheath adaxonal region
- Schmidt-Lanterman incisure
- membrane raft
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein homodimerization activity
- sialic acid binding
- carbohydrate binding
- receptor binding