Pipox Gene Summary [Rat]
Predicted to enable L-pipecolate oxidase activity and sarcosine oxidase activity. Predicted to be involved in L-lysine catabolic process to acetyl-CoA via L-pipecolate. Predicted to be active in peroxisome. Orthologous to human PIPOX (pipecolic acid and sarcosine oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pipox |
| Official Name | pipecolic acid and sarcosine oxidase [Source:RGD Symbol;Acc:1311347] |
| Ensembl ID | ENSRNOG00000008798 |
| Bio databases IDs | |
| Aliases | pipecolic acid and sarcosine oxidase |
| Synonyms | LPIPOX, Peroxisomal sarcosine oxidase, pipecolic acid and sarcosine oxidase, pipecolic acid oxidase, Pso, SOX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pipox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD dependent oxidoreductase TIGR03364
- FAD dependent oxidoreductase
- enzyme
- protein binding
- sarcosine oxidase, monomeric form
- L-pipecolate oxidase
- glycine oxidase ThiO
- sarcosine oxidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- rotator cuff injury
- hepatocellular carcinoma
- major depression
- alveolar rhabdomyosarcoma
- soft tissue sarcoma cancer
- gout
- weight gain
regulates
- L-lysine
role in cell
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Mitochondria
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pipox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- L-lysine catabolic process to acetyl-CoA via L-pipecolate
- lysine catabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- L-pipecolate oxidase activity
- flavin adenine dinucleotide binding
- sarcosine oxidase activity