Marcksl1 Gene Summary [Rat]
Predicted to enable actin filament binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration. Is active in presynaptic cytosol; presynaptic membrane; and synaptic vesicle. Orthologous to human MARCKSL1 (MARCKS like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Marcksl1 |
| Official Name | MARCKS-like 1 [Source:RGD Symbol;Acc:621197] |
| Ensembl ID | ENSRNOG00000009113 |
| Bio databases IDs | |
| Aliases | MARCKS-like 1 |
| Synonyms | D4Bc1, F52, LOC100911122, MACMARCK, MACMARCKS, MACS2, Macs3, MARCKS-like 1, MARCKS RELATED, MLP, MLP1, MRP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Marcksl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MARCKS family
- protein binding
- effector domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hydrocephalus
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- systolic dysfunction
- exencephaly
- spina bifida
- anencephaly
role in cell
- migration
- expression in
- proliferation
- morphology
- function
- density
- alignment
- organization
- size
- elongation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- presynaptic membrane
- synaptic vesicles
- growth cone
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Marcksl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- central nervous system development
- positive regulation of cell proliferation
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- extracellular vesicular exosome
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- calmodulin binding
- protein binding