Cnr2 Gene Summary [Rat]
Enables cannabinoid receptor activity. Involved in several processes, including negative regulation of GABAergic synaptic transmission; negative regulation of mast cell activation; and negative regulation of nitric-oxide synthase activity. Located in dendrite and neuronal cell body. Is extrinsic component of cytoplasmic side of plasma membrane. Is active in postsynaptic membrane. Used to study Huntington's disease; arthritis; and sciatic neuropathy. Biomarker of pancreatitis. Orthologous to human CNR2 (cannabinoid receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnr2 |
| Official Name | cannabinoid receptor 2 [Source:RGD Symbol;Acc:619713] |
| Ensembl ID | ENSRNOG00000009260 |
| Bio databases IDs | |
| Aliases | cannabinoid receptor 2 |
| Synonyms | Cannabinoid Receptor2, CB-2, CB2C, CB2-R, Cb2 Receptor, CNR2C, CX5, rCB2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cnr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- DRY motif
- cannabinoid receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Cnr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- G-Protein Coupled Receptor Signaling
- Gαi Signaling
- Parkinson's Signaling Pathway
- Reelin Signaling in Neurons
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- major depression
- pain
- post-traumatic stress disorder
- Huntington disease
- obesity
- breast cancer
- HIV-associated encephalitis
- motor dysfunction
- anorexia
role in cell
- apoptosis
- quantity
- expression in
- proliferation
- migration
- adhesion
- binding
- binding in
- signaling in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- cytoplasmic face of plasma membrane
- postsynaptic membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cnr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- negative regulation of action potential
- negative regulation of synaptic transmission, GABAergic
- immune response
- response to amphetamine
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of mast cell activation
- regulation of metabolic process
- response to lipopolysaccharide
- leukocyte chemotaxis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- extrinsic to internal side of plasma membrane
- endoplasmic reticulum
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cannabinoid receptor activity