Hivep3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription and skeletal muscle cell differentiation. Predicted to be active in nucleus. Orthologous to human HIVEP3 (HIVEP zinc finger 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hivep3 |
| Official Name | human immunodeficiency virus type I enhancer binding protein 3 [Source:RGD Symbol;Acc:1311252] |
| Ensembl ID | ENSRNOG00000009341 |
| Bio databases IDs | |
| Aliases | human immunodeficiency virus type I enhancer binding protein 3 |
| Synonyms | 2900056N03RIK, A130075N07, E030045D18RIK, HIVEP zinc finger 3, human immunodeficiency virus type I enhancer binding protein 3, KBP-1, KRC, LOC100507198, Rc, Schnurri-3, SHN3, ZAS3, ZNF40C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hivep3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- Zinc-finger double domain
- U1 zinc finger
- protein binding
- zinc finger domain
- acidic domain
- DNA binding
- ZAS domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- neoplasia
- dementia
- rheumatoid arthritis
- bronchopulmonary dysplasia
- Parkinson disease
- myopia
- organismal death
- metabolic syndrome X
- osteopenia
role in cell
- quantity
- proliferation
- activation in
- expression in
- differentiation
- number
- phosphorylation in
- production in
- function
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hivep3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle cell differentiation
- positive regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity