Crabp2 Gene Summary [Rat]
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | Crabp2 |
| Official Name | cellular retinoic acid binding protein 2 [Source:RGD Symbol;Acc:62070] |
| Ensembl ID | ENSRNOG00000048421 |
| Bio databases IDs | |
| Aliases | cellular retinoic acid binding protein 2 |
| Synonyms | cellular retinoic acid binding protein 2, cellular retinoic acid binding protein II, CRAB II, CRABP-II, Crabp(II), LOC108348208, RBP6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crabp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- protein binding
- retinoid binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
- cyclin binding
Pathways
Biological processes and signaling networks where the Crabp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypertrophic scarring
- idiopathic pulmonary fibrosis
- soft tissue sarcoma cancer
- organismal death
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- lung adenocarcinoma
- lung adenocarcinoma formation
- EGFR mutation positive adenocarcinoma of the lung
role in cell
- apoptosis
- proliferation
- expression in
- growth
- differentiation
- S phase
- signaling in
- cytostasis
- accumulation in
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crabp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of collateral sprouting
- fatty acid transport
- signal transduction
- epidermis development
- regulation of transcription, DNA-dependent
- retinoic acid metabolic process
- embryonic forelimb morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- protein binding
- fatty acid binding
- retinal binding
- cyclin binding
- retinol binding
- retinoid binding