Dusp5 Gene Summary [Rat]
Enables MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in negative regulation of DNA-templated transcription; negative regulation of vasoconstriction; and positive regulation of cerebral blood circulation. Predicted to be active in cytoplasm and nucleus. Orthologous to human DUSP5 (dual specificity phosphatase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp5 |
| Official Name | dual specificity phosphatase 5 [Source:RGD Symbol;Acc:620854] |
| Ensembl ID | ENSRNOG00000014061 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 5 |
| Synonyms | Cpg21, DSP5, dual specificity phosphatase 5, DUAL-SPECIFICITY protein PHOSPHATASE, DUSP, Gm337, HVH3, VH3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dusp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein tyrosine/serine/threonine phosphatase
- MAP kinase phosphatase
- protein-tyrosine-phoshatase
- phosphoprotein phosphatase
- Rhodanese Homology Domain
- phosphatase
- protein binding
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
- RHOD
Pathways
Biological processes and signaling networks where the Dusp5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- benign neoplasia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- cervical cancer
- androgenic alopecia
- chronic lymphocytic leukemia
- systemic lupus erythematosus
role in cell
- growth
- expression in
- phosphorylation in
- apoptosis
- differentiation
- proliferation
- migration
- activation in
- function
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dusp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERK1 and ERK2 cascade
- MAPK cascade
- peptidyl-threonine dephosphorylation
- negative regulation of MAPK cascade
- protein dephosphorylation
- endoderm formation
- dephosphorylation
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine/threonine phosphatase activity
- MAP kinase tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- phosphatase activity
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity