Hivep3 Gene Summary [Mouse]
Enables DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Located in nucleus. Is expressed in bone; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human HIVEP3 (HIVEP zinc finger 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Hivep3 |
| Official Name | human immunodeficiency virus type I enhancer binding protein 3 [Source:MGI Symbol;Acc:MGI:106589] |
| Ensembl ID | ENSMUSG00000028634 |
| Bio databases IDs | |
| Aliases | human immunodeficiency virus type I enhancer binding protein 3 |
| Synonyms | 2900056N03RIK, A130075N07, E030045D18RIK, HIVEP zinc finger 3, human immunodeficiency virus type I enhancer binding protein 3, KBP-1, KRC, LOC100507198, Rc, Schnurri-3, SHN3, ZAS3, ZNF40C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hivep3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- Zinc-finger double domain
- U1 zinc finger
- protein binding
- zinc finger domain
- acidic domain
- DNA binding
- ZAS domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- neoplasia
- dementia
- rheumatoid arthritis
- bronchopulmonary dysplasia
- Parkinson disease
- myopia
- organismal death
- metabolic syndrome X
- osteopenia
role in cell
- quantity
- proliferation
- activation in
- expression in
- differentiation
- number
- phosphorylation in
- production in
- function
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hivep3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle cell differentiation
- positive regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity