Ugt8 Gene Summary [Rat]
Enables N-acylsphingosine galactosyltransferase activity and UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in galactosylceramide biosynthetic process and response to immobilization stress. Located in endoplasmic reticulum. Orthologous to human UGT8 (UDP glycosyltransferase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ugt8 |
| Official Name | UDP glycosyltransferase 8 [Source:RGD Symbol;Acc:3938] |
| Ensembl ID | ENSRNOG00000009345 |
| Bio databases IDs | |
| Aliases | UDP glycosyltransferase 8 |
| Synonyms | Cerebroside Synthase, CGalT, CGT, mCerGT, UDP galactosyltransferase 8A, UDP glycosyltransferase 8, UGT4, Ugt8a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ugt8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- ceramide glucosyltransferase
- UDP-galactose-glucosylceramide beta-1,4-galactosyltransferase
- glycosyltransferase, MGT family
- 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
- enzyme
- UDP-glucoronosyl and UDP-glucosyl transferase
Pathways
Biological processes and signaling networks where the Ugt8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- growth failure
- ataxia
- Huntington disease
- tremor
- TCF3-PBX1 fusion positive acute lymphoblastic leukemia
- lung neuroendocrine carcinoma
role in cell
- apoptosis
- myelination
- degeneration
- morphogenesis
- differentiation
- organization
- assembly
- abnormal morphology
- spermatogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ugt8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- cytoskeleton organization
- paranodal junction assembly
- neuron projection morphogenesis
- peripheral nervous system development
- galactosylceramide biosynthetic process
- protein localization to paranode region of axon
- response to immobilization stress
- glycosphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
- 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity