Tm9sf4 Gene Summary [Rat]
Predicted to be involved in several processes, including positive regulation of protein localization; regulation of intracellular pH; and vacuolar proton-transporting V-type ATPase complex assembly. Predicted to be located in Golgi apparatus and early endosome. Predicted to be active in membrane. Orthologous to human TM9SF4 (transmembrane 9 superfamily member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tm9sf4 |
| Official Name | transmembrane 9 superfamily member 4 [Source:RGD Symbol;Acc:1307768] |
| Ensembl ID | ENSRNOG00000009406 |
| Bio databases IDs | |
| Aliases | transmembrane 9 superfamily member 4 |
| Synonyms | AA986553, AU045326, B930079E06, dJ836N17.2, mKIAA0255, transmembrane 9 superfamily member 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tm9sf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Endomembrane protein 70
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- inflammatory bowel disease
- chronic obstructive pulmonary disease
- idiopathic scoliosis
- metastasis
- advanced cancer
regulated by
role in cell
- migration
- phagocytosis by
- apoptosis
- invasiveness
- adhesion
- invasion by
- pH
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- early endosomes
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tm9sf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vacuolar proton-transporting V-type ATPase complex assembly
- regulation of intracellular pH
- response to hypoxia
- positive regulation of protein localization at cell surface
- phagocytosis
- positive regulation of protein exit from endoplasmic reticulum
- protein localization in membrane
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- early endosome
- membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding