Atp6v1h Gene Summary [Rat]
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in endocytosis and synaptic vesicle lumen acidification. Is extrinsic component of synaptic vesicle membrane. Orthologous to human ATP6V1H (ATPase H+ transporting V1 subunit H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v1h |
| Official Name | ATPase H+ transporting V1 subunit H [Source:RGD Symbol;Acc:1562450] |
| Ensembl ID | ENSRNOG00000030862 |
| Bio databases IDs | |
| Aliases | ATPase H+ transporting V1 subunit H |
| Synonyms | 0710001F19Rik, ATPase, H+ transporting, lysosomal V1 subunit H, ATPase H+ transporting V1 subunit H, CGI-11, MSTP042, NBP1, SFD, SFDalpha, SFDbeta, V-ATPase V1-H, VMA13, V-type ATPase H |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp6v1h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- VATPase_H
- H+-transporting two-sector ATPase
- protein binding
- V-ATPase subunit H
- transporter
Pathways
Biological processes and signaling networks where the Atp6v1h gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cellular membrane
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp6v1h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular pH reduction
- endosomal lumen acidification
- lysosomal lumen acidification
- regulation of macroautophagy
- vacuolar acidification
- endocytosis
Cellular Component
Where in the cell the gene product is active
- vacuolar proton-transporting V-type ATPase, V1 domain
- extracellular vesicular exosome
- proton-transporting V-type ATPase complex
- membrane
- cytosol
- endosome membrane
- Golgi membrane
- plasma membrane
- lysosomal membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein binding
- proton-transporting ATPase activity, rotational mechanism
- enzyme regulator activity