Tbc1d4 Gene Summary [Rat]
Predicted to enable GTPase activator activity. Involved in cellular response to insulin stimulus and negative regulation of vesicle fusion. Located in vesicle. Human ortholog(s) of this gene implicated in acanthosis nigricans. Orthologous to human TBC1D4 (TBC1 domain family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbc1d4 |
| Official Name | TBC1 domain family, member 4 [Source:RGD Symbol;Acc:1561609] |
| Ensembl ID | ENSRNOG00000009431 |
| Bio databases IDs | |
| Aliases | TBC1 domain family, member 4 |
| Synonyms | 5930406J04Rik, A930035N22, AS160, KIAA0603, LOC686547, NIDDM5, RGD1561609, TBC1 domain family member 4, TBC1 domain family, member 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbc1d4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Domain in Tre-2, BUB2p, and Cdc16p
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- Domain of unknown function (DUF3350)
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- insulin resistance
- abdominal aortic aneurysm
- venous thromboembolism
- noninsulin-dependent diabetes mellitus type 5
- colon cancer
- human papilloma virus infection
- oral cancer
- impaired glucose tolerance
role in cell
- expression in
- size
- liberation in
- binding in
- inactivation in
- exocytosis in
- retention in
- autophagy in
- proteolysis in
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- low-density microsomal fraction
- cytoplasmic vesicle membrane
- perinuclear region
- vesicles
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbc1d4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- vesicle-mediated transport
- negative regulation of vesicle fusion
Cellular Component
Where in the cell the gene product is active
- vesicle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity