Prokr1 Gene Summary [Rat]
Enables G protein-coupled receptor activity. Involved in negative regulation of apoptotic process. Predicted to be active in plasma membrane. Orthologous to human PROKR1 (prokineticin receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prokr1 |
| Official Name | prokineticin receptor 1 [Source:RGD Symbol;Acc:708443] |
| Ensembl ID | ENSRNOG00000009556 |
| Bio databases IDs | |
| Aliases | prokineticin receptor 1 |
| Synonyms | Bv8 receptor, EG-VEGFR1, GPR73, GPR73a, PK-R1, prokineticin receptor 1, ZAQ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prokr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Prokr1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- Hirschsprung disease
- heart failure
- hypoalgesia
- touch abnormality
- ischemic stroke
role in cell
- expression in
- apoptosis
- number
- survival
- angiogenesis by
- tubulation
- organization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prokr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- circadian rhythm
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide Y receptor activity