Hgfac Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation and zymogen activation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space and rough endoplasmic reticulum. Orthologous to human HGFAC (HGF activator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hgfac |
| Official Name | HGF activator [Source:RGD Symbol;Acc:70909] |
| Ensembl ID | ENSRNOG00000009572 |
| Bio databases IDs | |
| Aliases | HGF activator |
| Synonyms | hepatocyte growth factor activator, HGFA, HGF activator |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hgfac often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- serine-type peptidase
- peptidase
- FN1
- protein binding
- FN2
- EGF_CA
Pathways
Biological processes and signaling networks where the Hgfac gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- primary genetic hyperlipidemia
- liver cancer
- metabolic syndrome X
- coronary artery disease
- cardiovascular disorder
- epithelial cancer
- ischemic stroke
- Crohn disease
- inflammatory bowel disease
role in cell
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cell borders
- cytosol
- basal membrane
- rough endoplasmatic reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hgfac gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- zymogen activation
- proteolysis
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- rough endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- serine-type peptidase activity