Snph Gene Summary [Rat]
Involved in neuron differentiation. Located in mitochondrial membrane and neuronal cell body. Is active in presynaptic membrane. Orthologous to human SNPH (syntaphilin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snph |
| Official Name | syntaphilin [Source:RGD Symbol;Acc:1305867] |
| Ensembl ID | ENSRNOG00000009588 |
| Bio databases IDs | |
| Aliases | syntaphilin |
| Synonyms | 6430515A01, LOC102637610, mKIAA0374, Syntaphilin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snph often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding domain
- Golgi-localized syntaxin-1-binding clamp
- axon targeting domain
- transmembrane domain
- coiled-coil domain
- protein binding
- proline rich domain
- KHC binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- hemangioma
- angiomatosis
role in cell
- cell death
- mobility
- abnormal morphology
- oxidative stress response in
- paired-pulse facilitation
- regrowth
- motility
- function
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Mitochondria
- presynaptic membrane
- mitochondrial membrane
- synaptic vesicles
- synaptosomes
- synapse
- cytoplasmic microtubule
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snph gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic vesicle docking involved in exocytosis
- neuron differentiation
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- membrane
- cytoplasmic microtubule
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin-1 binding