Ptpmt1 Gene Summary [Rat]
Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrial inner membrane. Orthologous to human PTPMT1 (protein tyrosine phosphatase mitochondrial 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpmt1 |
| Official Name | protein tyrosine phosphatase, mitochondrial 1 [Source:RGD Symbol;Acc:1589783] |
| Ensembl ID | ENSRNOG00000009723 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, mitochondrial 1 |
| Synonyms | 1110001D10Rik, 2810004N20Rik, DUSP23, MOSP, PLIP, PNAS-129, protein tyrosine phosphatase mitochondrial 1, protein tyrosine phosphatase, mitochondrial 1, Topo2 α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptpmt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- phosphatase
- protein binding
- phosphoinositide 5-phosphatase
- PTP_DSP_cys
- phosphatidylglycerophosphatase
Pathways
Biological processes and signaling networks where the Ptpmt1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- failure to thrive
- chronic lymphocytic leukemia
- hypertension
regulated by
- decitabine
- tazemetostat
- trichostatin A
- SP2509
- SPP1
- alexidine
role in cell
- accumulation in
- apoptosis
- differentiation
- proliferation
- replication in
- cell death
- utilization by
- cell cycle progression
- upregulation in
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptpmt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of intrinsic apoptotic signaling pathway
- cardiolipin biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
- protein tyrosine phosphatase activity
- phosphatidylglycerophosphatase activity
- myosin phosphatase activity