Sfxn1 Gene Summary [Rat]
Predicted to enable L-alanine transmembrane transporter activity and L-serine transmembrane transporter activity. Predicted to be involved in L-alanine transport; L-serine transport; and serine import into mitochondrion. Predicted to act upstream of or within erythrocyte differentiation and iron ion transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SFXN1 (sideroflexin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sfxn1 |
| Official Name | sideroflexin 1 [Source:RGD Symbol;Acc:1308482] |
| Ensembl ID | ENSRNOG00000018279 |
| Bio databases IDs | |
| Aliases | sideroflexin 1 |
| Synonyms | 2810002O05Rik, A930015P12RIK, sideroflexin 1, SLC56A1, SLC64A1, TCC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sfxn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sideroflexins
- alanine transporter
- protein binding
- serine transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphoma
- Alzheimer disease
- lymphomagenesis
- Sengers syndrome
regulates
- one-carbon compound
- L-alanine
- L-serine
- iron ion
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sfxn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- L-alanine transport
- ion transmembrane transport
- iron ion transport
- L-serine transport
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane transporter activity
- ion transmembrane transporter activity
- L-serine transmembrane transporter activity
- L-alanine transmembrane transporter activity