Tpm3 Gene Summary [Rat]
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in brush border. Human ortholog(s) of this gene implicated in congenital myopathy 4A and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpm3 |
| Official Name | tropomyosin 3 [Source:RGD Symbol;Acc:621546] |
| Ensembl ID | ENSRNOG00000017441 |
| Bio databases IDs | |
| Aliases | tropomyosin 3 |
| Synonyms | CAPM1, CFTD, CMYO4A, CMYO4B, CMYP4A, CMYP4B, gamma-TM, HEL-189, HEL-S-82p, hscp30, hTM30nm, hTMnm, LOC286890, NEM1, OK/SW-cl.5, scl0002069.1 48, TM3, TM30, TM30nm, TM-5, Tm5NM, Tm5nm1-2, TMnm, TPM3nu, Tpm-5, TPMsk3, TRK, Trop-5, Tropomyosin2, tropomyosin 3, tropomyosin 3, gamma, tropomyosin 3, γ, Tropomyosin gamma, Tropomyosin γ, γ-TM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tpm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Tropomyosin
- Tropomyosin like
- protein binding
Pathways
Biological processes and signaling networks where the Tpm3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian cancer
- neoplasia
- epithelial cancer
- autosomal recessive congenital myopathy type 4B
- liver cancer
- bladder cancer
- TPM3-related myopathy
- Alzheimer disease
- hereditary disorder
- cap myopathy 1
role in cell
- cell death
- proliferation
- expression in
- invasion by
- migration
- morphology
- quantity
- assembly
- osmotic fragility
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- golgi/trans-golgi network-rich vesicle fraction
- cortical cytoskeleton
- transverse arc
- cytoskeleton
- cilia
- focal adhesions
- podosomes
- actin cytoskeleton
- Nucleus
- Mitochondria
- cytosol
- dorsal stress fiber
- ventral stress fiber
- dendritic spines
- growth cone
- neurites
- myofibrils
- cortical actin filaments
- actin stress fibers
- brush border
- cleavage furrow
- perikaryon
- phagosomes
- plasma
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tpm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoskeleton
- stress fiber
- actin cytoskeleton
- cytosol
- actin filament
- muscle thin filament tropomyosin
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding