Ctps1 Gene Summary [Rat]
Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in lymphocyte proliferation and nucleobase-containing small molecule metabolic process. Predicted to be active in cytoophidium and cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctps1 |
| Official Name | CTP synthase 1 [Source:RGD Symbol;Acc:1311060] |
| Ensembl ID | ENSRNOG00000009963 |
| Bio databases IDs | |
| Aliases | CTP synthase 1 |
| Synonyms | CTP A, CTPS, CTP synthase 1, CTP Synthetase, cytidine 5'-triphosphate synthase 1, GATD5, GATD5A, IMD24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctps1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTP binding site
- Glutamine amidotransferase class-I
- CTP synthase N-terminus
- CTP synthase
- enzyme
- protein binding
- identical protein binding
- Type 1 glutamine amidotransferase (GATase1)-like domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- severe combined immunodeficiency
- immunodeficiency 24
- androgenic alopecia
- adenoid cystic carcinoma
role in cell
- proliferation
- phosphorylation in
- expression in
- apoptosis
- G1 phase
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctps1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CTP biosynthetic process
- 'de novo' CTP biosynthetic process
- T cell proliferation
- glutamine metabolic process
- B cell proliferation
- response to xenobiotic stimulus
- nucleobase-containing compound metabolic process
- pyrimidine base biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoophidium
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- CTP synthase activity