Prpsap1 Gene Summary [Rat]
Enables enzyme regulator activity and kinase binding activity. Involved in negative regulation of kinase activity. Part of ribose phosphate diphosphokinase complex. Orthologous to human PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prpsap1 |
| Official Name | phosphoribosyl pyrophosphate synthetase-associated protein 1 [Source:RGD Symbol;Acc:620206] |
| Ensembl ID | ENSRNOG00000010083 |
| Bio databases IDs | |
| Aliases | phosphoribosyl pyrophosphate synthetase-associated protein 1 |
| Synonyms | 5730409F23RIK, PAP39, phosphoribosyl pyrophosphate synthetase-associated protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prpsap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- enzyme inhibitor activity
- Phosphoribosyl transferase (PRT)-type I domain
- ribose-phosphate pyrophosphokinase
- protein binding
- enzyme regulator activity
- Phosphoribosyl synthetase-associated domain
- PRK00934
- N-terminal domain of ribose phosphate pyrophosphokinase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prpsap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- purine nucleotide biosynthetic process
- nucleobase-containing compound metabolic process
- 5-phosphoribose 1-diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- ribose phosphate diphosphokinase complex
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein binding
- enzyme inhibitor activity
- ribose phosphate diphosphokinase activity