Enpp4 Gene Summary [Rat]
Predicted to enable bis(5'-adenosyl)-triphosphatase activity. Predicted to be involved in positive regulation of blood coagulation and purine ribonucleoside catabolic process. Predicted to be located in plasma membrane. Orthologous to human ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Enpp4 |
| Official Name | ectonucleotide pyrophosphatase/phosphodiesterase 4 [Source:RGD Symbol;Acc:1308689] |
| Ensembl ID | ENSRNOG00000010174 |
| Bio databases IDs | |
| Aliases | ectonucleotide pyrophosphatase/phosphodiesterase 4 |
| Synonyms | 4933413N07RIK, ectonucleotide pyrophosphatase/phosphodiesterase 4, Gm90, KIAA0879, NPP4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Enpp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- Type I phosphodiesterase / nucleotide pyrophosphatase
- Bis(5'-adenosyl)-triphosphatase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- secretory granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Enpp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- purine ribonucleoside catabolic process
- positive regulation of blood coagulation
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- bis(5'-adenosyl)-triphosphatase activity