Lpar1 Gene Summary [Rat]
Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in several processes, including cellular response to 1-oleoyl-sn-glycerol 3-phosphate; nervous system development; and regulation of vesicle-mediated transport. Located in dendritic shaft; dendritic spine; and neuronal cell body. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study hepatocellular carcinoma and transient cerebral ischemia. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpar1 |
| Official Name | lysophosphatidic acid receptor 1 [Source:RGD Symbol;Acc:620563] |
| Ensembl ID | ENSRNOG00000013656 |
| Bio databases IDs | |
| Aliases | lysophosphatidic acid receptor 1 |
| Synonyms | clone 4.9, EDG2, ENDOTHELIAL DIFFERENTIATION LYSOPHOSPHATIDIC ACID G-protein-COUPLED receptor 2, Gpcr26, Kdt2, LPA1, LPA1 receptor, LPA2, LPA receptor 1, LYSOPHOSPHATIDIC ACID G-protein-COUPLED receptor, lysophosphatidic acid receptor 1, Mrec1.3, rec.1.3, VZG1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lpar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- phospholipid binding
- bioactive lipid receptor
- binding protein
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Lpar1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- cancer
- epithelial cancer
- hypertension
- neoplasia
- oral squamous cell carcinoma
- angioimmunoblastic T-cell lymphoma
- growth failure
- prostate cancer
- survival
role in cell
- expression in
- phosphorylation in
- proliferation
- growth
- quantity
- accumulation in
- apoptosis
- activation in
- assembly
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- perinuclear membrane
- cellular membrane
- Nucleus
- endosomes
- primary cilia
- presynaptic membrane
- postsynaptic membrane
- dendritic spines
- synapse
- endocytotic vesicle
- perikaryon
- dendritic shafts
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lpar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- regulation of cell shape
- oligodendrocyte development
- positive regulation of Rho protein signal transduction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- neurogenesis
- myelination
- cell chemotaxis
- optic nerve development
- cellular response to oxygen levels
- positive regulation of smooth muscle cell chemotaxis
- negative regulation of neuron projection development
- regulation of metabolic process
- bleb assembly
- G-protein coupled receptor signaling pathway
- cerebellum development
- positive regulation of dendritic spine development
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- negative regulation of cAMP-mediated signaling
- elevation of cytosolic calcium ion concentration
- corpus callosum development
- positive regulation of stress fiber assembly
- positive regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- endocytic vesicle
- endosome
- postsynaptic membrane
- cytoplasm
- dendritic shaft
- dendritic spine
- neuronal cell body
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- lysophosphatidic acid receptor activity
- G-protein coupled receptor activity
- protein binding
- lysophosphatidic acid binding
- G-protein alpha-subunit binding
- PDZ domain binding