Serpini1 Gene Summary [Rat]
Enables serine-type endopeptidase inhibitor activity. Involved in positive regulation of neuron projection development. Predicted to be located in neuronal cell body and secretory granule lumen. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINI1 (serpin family I member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpini1 |
| Official Name | serpin family I member 1 [Source:RGD Symbol;Acc:619896] |
| Ensembl ID | ENSRNOG00000010248 |
| Bio databases IDs | |
| Aliases | serpin family I member 1 |
| Synonyms | HNS-S1, HNS-S2, neuroserpin, Ns, PI-12, Pi17, raPIT5a, serine (or cysteine) peptidase inhibitor, clade I, member 1, SERINE (OR CYSTEINE) PROTEINASE INHIBITOR, Serine protease inhibitor 1, serpin family I member 1, Spi17 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpini1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial encephalopathy with neuroserpin inclusion bodies
- Huntington disease
- hypertension
- pulmonary emphysema
- glioblastoma
- glioblastoma cancer
- edema
- neurological disorder
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- activation
- cell death
- quantity
- survival
- transcription in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- organelle lumens
- vesicles
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpini1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- negative regulation of endopeptidase activity
- peripheral nervous system development
- positive regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- secretory granule lumen
- neuronal cell body
- perikaryon
- cytoplasmic membrane-bounded vesicle lumen
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity