Pde8b Gene Summary [Rat]
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 3. Orthologous to human PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde8b |
| Official Name | phosphodiesterase 8B [Source:RGD Symbol;Acc:735041] |
| Ensembl ID | ENSRNOG00000010280 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 8B |
| Synonyms | ADSD, B230331L10RIK, C030047E14RIK, phosphodiesterase 8B, PPNAD3, RNPDE8B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde8b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'5'-cyclic nucleotide phosphodiesterase
- PAS domain
- PAS domain S-box
- cAMP-specific phosphodiesterase
- PAS
- enzyme
- HDc
- PAS fold
- PDE8 phosphodiesterase
- 3',5'-cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the Pde8b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- acute myeloid leukemia
- hereditary disorder
- asthma
- autosomal dominant striatal degeneration
- isolated micronodular adrenocortical disease
- ocular itching
- ragweed allergy
- perennial allergic rhinitis
- allergic conjunctivitis
regulates
- insulin
- TSH
- steroidogenic enzyme
- corticosterone
- steroid hormone
role in cell
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde8b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of steroid hormone biosynthetic process
- cAMP catabolic process
- visual learning
- cAMP-mediated signaling
- neuromuscular process controlling balance
- behavioral fear response
- operant conditioning
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity