Pou2af1 Gene Summary [Rat]
Predicted to enable DNA binding activity and transcription coactivator activity. Predicted to be involved in cellular response to virus; germinal center B cell differentiation; and positive regulation of macromolecule biosynthetic process. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human POU2AF1 (POU class 2 homeobox associating factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou2af1 |
| Official Name | POU class 2 homeobox associating factor 1 [Source:RGD Symbol;Acc:1594728] |
| Ensembl ID | ENSRNOG00000011500 |
| Bio databases IDs | |
| Aliases | POU class 2 homeobox associating factor 1 |
| Synonyms | BOB1, BOB.1, LOC684630, OBF-1, OBF.1, OCA-B, POU class 2 homeobox associating factor 1, POU domain, class 2, associating factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pou2af1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- transcription co-activator
- myristoylation sequence
- transcription cofactor
- protein binding
- POU domain, class 2, associating factor 1
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- COVID-19
- multiple sclerosis
- vascular dementia
- diabetic nephropathy
- agammaglobulinemia
- Hodgkin lymphoma
- Hodgkin disease
- chronic obstructive pulmonary disease
- mediastinal gray zone lymphoma
role in cell
- quantity
- proliferation
- apoptosis
- expression in
- phosphorylation in
- number
- upregulation in
- function
- differentiation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pou2af1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germinal center B cell differentiation
- humoral immune response
- positive regulation of interleukin-6 production
- positive regulation of transcription from RNA polymerase II promoter
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- POU domain binding