Nrgn Gene Summary [Rat]
Enables calmodulin binding activity; phosphatidic acid binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in associative learning; modulation of chemical synaptic transmission; and telencephalon development. Located in several cellular components, including dendritic spine head; neuronal cell body; and trans-Golgi network transport vesicle membrane. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of hypothyroidism. Orthologous to human NRGN (neurogranin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrgn |
| Official Name | neurogranin [Source:RGD Symbol;Acc:61833] |
| Ensembl ID | ENSRNOG00000010688 |
| Bio databases IDs | |
| Aliases | neurogranin |
| Synonyms | 0710001B06Rik, AI838505, BICKS, hng, Neurogranin, NG, NG/RC3, Pss1, RC3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nrgn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- binding protein
- calmodulin binding
- phosphatidylinositol-3,4,5-triphosphate binding
- IQ domain
- calmodulin binding domain
Pathways
Biological processes and signaling networks where the Nrgn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Huntington disease
- schizophrenia
- pervasive developmental disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- major depression
- Alzheimer disease
- pemphigus vulgaris
- bipolar disorder
role in cell
- apoptosis
- synaptic transmission
- signal transduction in
- excitability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cytosol
- postsynaptic membrane
- trans Golgi network
- mitochondrial membrane
- dendritic spine head
- neurites
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nrgn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- nervous system development
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- calmodulin binding