RGD1561590 Gene Summary [Rat]
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | RGD1561590 |
| Official Name | similar to SAP18 [Source:RGD Symbol;Acc:1561590] |
| Ensembl ID | ENSRNOG00000010732 |
| Bio databases IDs | |
| Aliases | similar to SAP18 |
| Synonyms | 2HOR0202, C530046K05Rik, D11Ertd539e, EMegR4, Sap18a, SAP18P, Sin3A associated protein 18, Sin3-associated polypeptide 18, Sinbp1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgd1561590 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-repressor
- Sin3 associated polypeptide p18 (SAP18)
- protein binding
Pathways
Biological processes and signaling networks where the Rgd1561590 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
role in cell
- apoptosis
- cell death
- alternative splicing by
- splicing by
- alternative splicing in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- cytosol
- inner nuclear membrane
- nucleoplasm
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgd1561590 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- negative regulation of transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- negative regulation of nuclear mRNA splicing, via spliceosome
- positive regulation of apoptotic process
- mRNA processing
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- nuclear body
- nuclear speck
- cytosol
- histone deacetylase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- transcription corepressor activity
- transcription factor binding