Eloa Gene Summary [Rat]
Predicted to enable double-stranded DNA binding activity. Involved in regulation of transcription by RNA polymerase II and transcription elongation by RNA polymerase II. Located in site of DNA damage. Part of transcription elongation factor complex. Orthologous to human ELOA (elongin A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eloa |
| Official Name | elongin A [Source:RGD Symbol;Acc:3827] |
| Ensembl ID | ENSRNOG00000010902 |
| Bio databases IDs | |
| Aliases | elongin A |
| Synonyms | El, ELOA1, Elongin A, SIII, SIII p110, TCEB3, TCEB3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eloa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- transcription regulator
- TFIIS helical bundle-like domain
- double-stranded DNA binding
- RNA polymerase II transcription factor SIII (Elongin) subunit A
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- developmental delay
- hypoplasia
- psoriasis
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- organismal death
- growth failure
- gastric cancer
- infection by HIV-1
regulated by
- dexamethasone
- thapsigargin
- triptolide
- alpha-amanitin
- histidinol
- methyl methanesulfonate
- olaparib
- dichlororibofuranosylbenzimidazole
- tretinoin
- ELOC
role in cell
- binding in
- migration
- expression in
- cell death
- apoptosis
- growth
- proliferation
- dissociation in
- degradation in
- JQ1 resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eloa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- extracellular space
- elongin complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding